Isaac Negrene was born in Natal, RN, Brazil. At the age of 16, he heard some of his friends playing Brazilian popular music, and that was the main trigger for his interest in learning guitar.
Isaac studied harmony and improvisation at UFRN (Federal University of Rio Grande do Norte) with guitarist Manoca Barreto. Soon after finishing the course, Isaac became a busy recording artist, producer, and sideman. This helped him to develop an eclectic and original style, moving through various musical genres with ease.
He has performed in venues like New Morning (Paris), Ronnie Scott's (London), MC Theater - Paradiso (Amsterdam), Pretol Club (Antwerp - Belgium), Rockstore (Montpellier - France), Espaço Brasil (Lisbon - Portugal), among other presentations in theaters and jazz festivals in Buenos Aires (Argentina), Montevideo and Mercerdes (Uruguay), Bogota (Colombia), Madrid and Zaragoza (Spain).
As a sideman, he worked with renowned artists like: Ed Motta, Elza Soares, Chico Cezar, Claudio Zoli, Toni Garrido, Tony Tornado, Pee Wee Ellis (James Brown), Guida de Palma (Portugual), Jesuton and Heidi Vogel (England).
Isaac currently lives in São Paulo and is a member of the Banda Black Rio, an internationally acclaimed group. The group frequently tours inside and outside Brazil.